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Tegretol is used to treat seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy.

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Hepatic effectsranging from slight elevations in liver enzymes to rare cases of hepatic failure have been reportedsee ADVERSE REACTIONS and PRECAUTIONSLaboratory TestsIn some caseshepatic effects may progress despite discontinuation of the drugIn addition rare instances of vanishing bile duct syndrome have been reportedThis syndrome consists of a cholestatic process with a variable clinical course ranging from fulminant to indolentinvolving the destruction and disappearance of the intrahepatic bile ductsSomebut not allcases are associated with features that overlap with other immunoallergenic syndromes such as multiorgan hypersensitivityDRESS syndromeand serious dermatologic reactionsAs an example there has been a report of vanishing bile duct syndrome associated with Stevens-Johnson syndrome and in another case an association with fever and eosinophilia.

Have a history of bone marrow depressionare allergic to carbamazepine or any of the ingredients in TEGRETOLSee the end of this Medication Guide for a complete list of ingredients in TEGRETOLtake nefazodoneare allergic to medicines called tricyclic antidepressantsTCAsAsk your healthcare provider or pharmacist for a list of these medicines if you are not surehave taken a medicine called a Monoamine Oxidase InhibitorMAOIin the last 14 daysAsk your healthcare provider or pharmacist for a list of these medicines if you are not sure.

Have a history of bone marrow depressionare allergic to carbamazepine or any of the ingredients in TEGRETOLSee the end of this Medication Guide for a complete list of ingredients in TEGRETOLtake nefazodoneare allergic to medicines called tricyclic antidepressantsTCAsAsk your healthcare provider or pharmacist for a list of these medicines if you are not surehave taken a medicine called a Monoamine Oxidase InhibitorMAOIin the last 14 daysAsk your healthcare provider or pharmacist for a list of these medicines if you are not sure.

Substantial evidence of Tegretol’s effectiveness for use in the management of children with epilepsysee INDICATIONS AND USAGE for specific seizure typesis derived from clinical investigations performed in adults and from studies in several in vitro systems which support the conclusion that1the pathogenetic mechanisms underlying seizure propagation are essentially identical in adults and childrenand2the mechanism of action of carbamazepine in treating seizures is essentially identical in adults and children.

Coadministration of carbamazepine and nefazodone may result in insufficient plasma concentrations of nefazodone and its active metabolite to achieve a therapeutic effectCoadministration of carbamazepine with nefazodone is contraindicated.

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tegretol is an anticonvulsant drug available by prescription only.