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Metformin hydrochloride is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabeteslowering both basal and postprandial plasma glucoseMetformin hydrochloride decreases hepatic glucose productiondecreases intestinal absorption of glucoseand improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drinkBe sure your family and close friends know how to give you this injection in an emergency.

Certain drugs tend to produce hyperglycemia and may lead to loss of blood glucose controlThese drugs include thiazides and other diureticscorticosteroidsphenothiazinesthyroid productsestrogensoral contraceptivesphenytoinnicotinic acidsympathomimeticscalcium channel blocking drugsand isoniazidWhen such drugs are administered to a patient receiving Glucovancethe patient should be closely observed for loss of blood glucose controlWhen such drugs are withdrawn from a patient receiving Glucovancethe patient should be observed closely for hypoglycemiaMetformin is negligibly bound to plasma proteins and isthereforeless likely to interact with highly protein-bound drugs such as salicylatessulfonamideschloramphenicoland probenecid as compared to sulfonylureaswhich are extensively bound to serum proteins.

Blood sugar levels can be affected by stressillnesssurgeryexercisealcohol useor skipping mealsAsk your doctor before changing your dose or medication schedule.

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after administration of a single oral glucovance mite tablet with food, dose-normalized geometric mean glucovance mite c max and auc in pediatric patients with type 2 diabetes 11-16 years of age, n 28, mean body weight of 97 kg differed 6 from historical values in healthy adults.