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Information about Viramune.

Viramune should not be used as the sole active antiretroviralas monotherapy with any antiretroviral has shown to result in viral resistance.

The dose should not be increased to the maintenance dose until any rash has clearedIf the patient cannot switch to the full dose within four weeks of starting Viramunealternative treatments should be sought.

Concomitant use of etravirine with nevirapine may cause a significant decrease in the plasma concentrations of etravirine and loss of therapeutic effect of etravirine.

Results of in vitro studies showed a weak antagonism of nevirapine by adefovirsee section 5.1this has not been confirmed in clinical trials and reduced efficacy is not expectedAdefovir did not influence any of the common CYP isoforms known to be involved in human drug metabolism and is excreted renallyNo clinically relevant drug-drug interaction is expected.

Viramune should not be used as the sole active antiretroviralas monotherapy with any antiretroviral has shown to result in viral resistance.

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