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AffiliationInterfaculty Institute for Genetics and Functional GenomicsUniversity Medicine GreifswaldGreifswaldGermany.

The SERPINA1 gene provides instructions for making a protein called alpha-1 antitrypsinwhich is a type of serine protease inhibitorserpinSerpins help control several types of chemical reactions by blockinginhibitingthe activity of certain enzymesAlpha-1 antitrypsin prevents the digestive enzyme trypsin from breaking down proteins until trypsin reaches the intestinesAlpha-1 antitrypsin also inhibits other enzymesincluding a powerful enzyme called neutrophil elastase that is released from white blood cells to fight infection.

AffiliationCentre for Cognitive Ageing and Cognitive EpidemiologyDepartment of PsychologyUniversity of EdinburghEdinburghUnited Kingdom.

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