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Do not swallow the tablet wholeAllow it to dissolve in your mouth without chewingIf desiredyou may drink liquid to help swallow the dissolved tablet.

Serotonin syndromeincluding altered mental statusautonomic instability and neuromuscular abnormalitieshas been reported following concomitant treatment with triptans and selective serotonin reuptake inhibitorsSSRIsor serotonin noradrenaline reuptake inhibitorsSNRIsThese reactions can be severeIf concomitant treatment with rizatriptan and an SSRI or SNRI is clinically warrantedappropriate observation of the patient is advisedparticularly during treatment initiationwith dose increasesor with addition of another serotonergic medicationsee section 4.5

Selective Serotonin Reuptake InhibitorsSSRIsSerotonin Norepinephrine Reuptake InhibitorsSNRIsand Serotonin SyndromeThere have been reports describing patients with symptoms compatible with serotonin syndromeincluding altered mental statusautonomic instability and neuromuscular abnormalitiesfollowing the use of selective serotonin reuptake inhibitorsSSRIsor serotonin noradrenaline reuptake inhibitorsSNRIsand triptanssee section 4.4

Effect of FoodThe absorption of rizatriptan is delayed by approximately 1 hour when administered together with foodThereforeonset of effect may be delayed when rizatriptan is administered in the fed statesee also Pharmacokinetic propertiesAbsorption

Migraine or treatment with MAXALT may cause somnolence in some patientsDizziness has also been reported in some patients receiving MAXALTPatients shouldthereforeevaluate their ability to perform complex tasks during migraine attacks and after administration of MAXALT.

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