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Thus far, all of the emsam efficacy studies have compared it to placebo, so we have no head-to-head data versus other antidepressants.

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The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotoninExamples include street drugs such as MDMAecstasyStJohn’s wortdextromethorphancertain antidepressantsincluding SSRIs such as fluoxetine/paroxetineSNRIs such as duloxetine/venlafaxineTCAs such as amitriptyline/doxepincertain narcotic medicationssuch as meperidinemethadonepentazocinepropoxyphenetramadoltapentadolamong othersThe risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs.

You should not use Emsam if you are allergic to selegilineor if you have pheochromocytomatumor of the adrenal gland

Tell your health care professional if you have any side effect that bothers you or does not go awayThese are not all the side effects of EMSAMFor more informationask your health care professional or pharmacist.

Thoughts about suicide or dying attempts to commit suicide new or worse depression new or worse anxiety feeling agitatedrestlessangry or irritable panic attacks trouble sleeping new or worse irritability acting aggressivebeing angry or violent acting on dangerous impulses an extreme increase in activity or talkingmaniaother unusual changes in behavior or mood.

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