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Select the initial dose based on the expected maintenance dosetaking into account the above factorsModify this dose based on consideration of patient-specific clinical factorsConsider lower initial and maintenance doses for elderly and/or debilitated patients and in Asian patientssee Use In Specific Populations and CLINICAL PHARMACOLOGYRoutine use of loading doses is not recommended as this practice may increase hemorrhagic and other complications and does not offer more rapid protection against clot formation.

Some mixtures of medications can lead to serious and even fatal consequences.

Frequency not reportedCerebral hemorrhagecerebral subdural hematomalethargyheadachedizzinesstaste perversionparesthesiaRef]

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