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Large doses of estrogen5 mg conjugated estrogens per daycomparable to those used to treat cancer of the prostate and breasthave been shown in a large prospective clinical trial in men to increase the risks of nonfatal myocardial infarctionpulmonary embolismand thrombophlebitis.

Safety and effectiveness in pediatric patients have not been establishedLarge and repeated doses of estrogen over an extended period of time have been shown to accelerate epiphyseal closureresulting in short adult stature if treatment is initiated before the completion of physiologic puberty in normally developing childrenIn patients in whom bone growth is not completeperiodic monitoring of bone maturation and effects on epiphyseal centers is recommended.

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