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Anaphylactic reactions have been reporteddeath has also been reported in association with this eventPossible cross-sensitivity with other alkylating agents has been reportedSIADHsyndrome of inappropriate ADH secretionhas been reported with the use of cyclophosphamideMalaise and asthenia have been reported as part of the postmarketing experience.

Sometimesmesna is used concomitantly as prophylaxis against hemorrhagic cystitis.

AGenerally acceptableControlled studies in pregnant women show no evidence of fetal risk.

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when used in combination with other antineoplastic agents may decrease the dose cytoxana and other drugs.