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The long-term efficacy of rosuvastatin therapy initiated in childhood to reduce morbidity and mortality in adulthood has not been established.

Rosuvastatin was not mutagenic or clastogenic with or without metabolic activation in the Ames test with Salmonella typhimurium and Escherichia colithe mouse lymphoma assayand the chromosomal aberration assay in Chinese hamster lung cellsRosuvastatin was negative in the in vivo mouse micronucleus test.

It is recommended that liver enzyme tests be performed before the initiation of CRESTORand if signs or symptoms of liver injury occur.

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you are allergic to any ingredient in crestor you have liver problems or unexplained abnormal liver function tests you are pregnant or breast-feeding you are taking itraconazole, mibefradil, or telithromycin.