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Notable requirements of the clozaril rems program include .

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The dosage must be adjusted individuallyFor each patient the lowest effective dose should be usedFor doses not realisable/practicable with one strengthother strengths of this medicinal product are availableCautious titration and a divided dosage schedule are necessary to minimise the risks of hypotensionseizure and sedation.

Patients in whom Clozaril has been discontinued as a result of either WBC or ANC deficienciessee abovemust not be re-exposed to Clozaril.

In the event of planned termination of Clozaril therapya gradual reduction in dose over a 1 to 2-week period is recommendedIf abrupt discontinuation is necessarythe patient should be carefully observed for the occurrence of withdrawal reactionssee section 4.4

Treatment must be discontinued immediately in the event of neutropenia or agranulocytosissee section 4.4In this situationcareful psychiatric monitoring of the patient is essential since symptoms may recur quickly.

Concomitant use of lithium or other CNS-active agents may increase the risk of development of neuroleptic malignant syndromeNMS

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clozaril belongs to the class of medications known as atypical antipsychotics or second generation psychotics.