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With copegus and peginterferon are at increased.

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Serious adverse events include neuropsychiatric disorderssuicidal ideation and suicide attemptserious and severe bacterial infectionsbone marrow toxicitycytopenia and rarelyaplastic anemiacardiovascular disordershypertensionarrhythmias and myocardial infarctionhypersensitivityincluding anaphylaxisendocrine disordersincluding thyroid disorders and diabetes mellitusautoimmune disordersincluding psoriasis and lupuspulmonary disordersdyspneapneumoniabrochiolitis obliteransinterstitial pneumonitis and sarcoidosiscolitisulcerative and hemorrhagic/ischemiccolitispancreatitisand opthalmologic disordersdecrease or loss of visionretinopathy including macular edema and retinal thrombosis/hemorrhagesoptic neuritis and papilledema

Before treatment startspatients should talk to their doctor about all their health conditionsincluding if they:

People with infants who are taking ribavirin should not breastfeed or nurse their children.

It is not known whether ribavirin passes into breast milk or if it could harm a nursing babyYou should not breast-feed while you are taking ribavirin.

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-patients who reach their 18th birthday while receiving peginterferon alfa-2a plus copegus should remain on the pediatric dosing regimen.