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When methotrexate is less effectiveWhen methotrexate is used with certain drugsit may not work as well to treat your conditionThis is because the amount of methotrexate in your body may be decreasedExamples of these drugs include:

Methotrexate is used to treat certain types of cancer of the breastskinhead and neckor lungIt is also used to treat severe psoriasis and rheumatoid arthritis.

Dehydrationlow fluid levels in your bodycan worsen the side effects of this drugBe sure to drink enough fluids before taking this drugMethotrexate can cause mouth soresTaking a folic acid supplement may decrease this side effectIt may also help decrease certain kidney or liver side effects from methotrexateYour doctor can tell you more.

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however, his little friend is on regimen c which had a higher dose of methotrexate along with other drugs – he did sooo well.