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For men use birth control to prevent pregnancy while using hydrea and for at least 1 year after your treatment ends.

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Hydroxyurea is clastogenic in vitrohamster cellshuman lymphoblastsand in vivoSCE assay in rodentsmouse micronucleus assayHydroxyurea causes the transformation of rodent embryo cells to a tumorigenic phenotype.

Keep these considerations in mind if your doctor prescribes hydroxyurea for you.

Three mechanisms of action have been postulated for the increased effectiveness of concomitant use of hydroxyurea therapy with irradiation on squamous cellepidermoidcarcinomas of the head and neckIn vitro studies utilizing Chinese hamster cells suggest that hydroxyurea1is lethal to normally radioresistant S-stage cellsand2holds other cells of the cell cycle in the G1 or pre-DNA synthesis stage where they are most susceptible to the effects of irradiationThe third mechanism of action has been theorized on the basis of in vitro studies of HeLa cellsIt appears that hydroxyureaby inhibition of DNA synthesishinders the normal repair process of cells damaged but not killed by irradiationthereby decreasing their survival rateRNA and protein syntheses have shown no alteration.

Hydroxyurea passes into breast milk and may have undesirable effects on a nursing infantBreast-feeding while using this drug is not recommendedConsult your doctor before breast-feeding.

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